Generation of two human iPSC lines with Exon 3 mutations in BCL2-Associated Athanogene 3 (BAG3) from dilated cardiomyopathy patients

Generation of two human iPSC lines with Exon 3 mutations in BCL2-Associated Athanogene 3 (BAG3) from dilated cardiomyopathy patients

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Dilated cardiomyopathies (DCM) are one of the main Bird Feeder causes of heart failure as one ages.BAG3 is a chaperone protein that is heavily implicated in the development of DCM and speed of progression toward heart failure.Here we generate two human iPSC lines from individuals with mutations in exon 3 of BAG3 and provide validation of their pluripotency and ability to differentiate toward the three primary germ layers.These two cell lines can 3 Piece Power Reclining Sectional with Chaise help our understanding of BAG3 and its role in DCM by providing a good model for BAG3 inactivation and insufficiency.